Familial adenomatous polyposis: from bedside to bench and vice versaA tribute to the somatic cell geneticist P. Meera Khan
G Griffioen, HFA Vasen, HW Verspaget… - Cytogenetics and Cell …, 1999 - karger.com
G Griffioen, HFA Vasen, HW Verspaget, C Lamers
Cytogenetics and Cell genetics, 1999•karger.comFamilial adenomatous polyposis (FAP) is characterized by the presence of numerous
adenomatous polyps in the colorectum, as well as an autosomal dominant mode of
inheritance. This syndrome will inevitably lead to colorectal cancer when left untreated, and
it is estimated that 1% of all colorectal cancer cases are due to it. Over the past 20 years
molecular genetic studies on FAP patients have laid down the basis for the elucidation of the
genetic phenomena that ultimately result in the development of colorectal cancer. Professor …
adenomatous polyps in the colorectum, as well as an autosomal dominant mode of
inheritance. This syndrome will inevitably lead to colorectal cancer when left untreated, and
it is estimated that 1% of all colorectal cancer cases are due to it. Over the past 20 years
molecular genetic studies on FAP patients have laid down the basis for the elucidation of the
genetic phenomena that ultimately result in the development of colorectal cancer. Professor …
Abstract
Familial adenomatous polyposis (FAP) is characterized by the presence of numerous adenomatous polyps in the colorectum, as well as an autosomal dominant mode of inheritance. This syndrome will inevitably lead to colorectal cancer when left untreated, and it is estimated that 1% of all colorectal cancer cases are due to it. Over the past 20 years molecular genetic studies on FAP patients have laid down the basis for the elucidation of the genetic phenomena that ultimately result in the development of colorectal cancer. Professor P. Meera Khan was one of the leading authorities in the world of molecular genetics of colorectal cancer in general and of FAP in particular. His scientific contributions from the pre-DNA era up to the recent implementation of molecular genetic research in daily clinical practice have helped revolutionize our approach and management of FAP patients and their relatives.
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